Notice (8): file_put_contents(): Write of 270 bytes failed with errno=28 No space left on device [CORE/src/Log/Engine/FileLog.php, line 140]

        if (!$mask) {
            file_put_contents($pathname, $message . "\n", FILE_APPEND);

file_put_contents - [internal], line ??
Cake\Log\Engine\FileLog::log() - CORE/src/Log/Engine/FileLog.php, line 140
Cake\Log\Log::write() - CORE/src/Log/Log.php, line 392
Cake\Log\Log::warning() - CORE/src/Log/Log.php, line 477
DebugKit\ToolbarService::isSuspiciouslyProduction() - ROOT/vendor/cakephp/debug_kit/src/ToolbarService.php, line 169
DebugKit\ToolbarService::isEnabled() - ROOT/vendor/cakephp/debug_kit/src/ToolbarService.php, line 105
DebugKit\Plugin::bootstrap() - ROOT/vendor/cakephp/debug_kit/src/Plugin.php, line 48
Cake\Http\BaseApplication::pluginBootstrap() - CORE/src/Http/BaseApplication.php, line 182
Cake\Http\Server::bootstrap() - CORE/src/Http/Server.php, line 111
Cake\Http\Server::run() - CORE/src/Http/Server.php, line 79
[main] - ROOT/webroot/index.php, line 40

Notice (8): SplFileObject::fwrite() [<a href='https://secure.php.net/splfileobject.fwrite'>splfileobject.fwrite</a>]: Write of 5437 bytes failed with errno=28 No space left on device [CORE/src/Cache/Engine/FileEngine.php, line 141]

Code Context

        $success = $this->_File->ftruncate(0) &&
            $this->_File->fwrite($contents) &&
            $this->_File->fflush();

SplFileObject::fwrite() - [internal], line ??
Cake\Cache\Engine\FileEngine::set() - CORE/src/Cache/Engine/FileEngine.php, line 141
Cake\Database\Schema\CachedCollection::describe() - CORE/src/Database/Schema/CachedCollection.php, line 85
Cake\ORM\Table::getSchema() - CORE/src/ORM/Table.php, line 513
Cake\ORM\Query::addDefaultTypes() - CORE/src/ORM/Query.php, line 290
Cake\ORM\Query::__construct() - CORE/src/ORM/Query.php, line 184
Cake\ORM\Table::query() - CORE/src/ORM/Table.php, line 1702
Cake\ORM\Table::find() - CORE/src/ORM/Table.php, line 1263
App\Controller\NewsController::action_() - APP/Controller/NewsController.php, line 6426
App\Controller\NewsController::get_data() - APP/Controller/NewsController.php, line 5701
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5625
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3436
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317

Notice (8): SplFileObject::fwrite() [<a href='https://secure.php.net/splfileobject.fwrite'>splfileobject.fwrite</a>]: Write of 822 bytes failed with errno=28 No space left on device [CORE/src/Cache/Engine/FileEngine.php, line 141]

Code Context

        $success = $this->_File->ftruncate(0) &&
            $this->_File->fwrite($contents) &&
            $this->_File->fflush();

SplFileObject::fwrite() - [internal], line ??
Cake\Cache\Engine\FileEngine::set() - CORE/src/Cache/Engine/FileEngine.php, line 141
Cake\Database\Schema\CachedCollection::describe() - CORE/src/Database/Schema/CachedCollection.php, line 85
Cake\ORM\Table::getSchema() - CORE/src/ORM/Table.php, line 513
Cake\ORM\Query::addDefaultTypes() - CORE/src/ORM/Query.php, line 290
Cake\ORM\Query::__construct() - CORE/src/ORM/Query.php, line 184
Cake\ORM\Table::query() - CORE/src/ORM/Table.php, line 1702
Cake\ORM\Table::find() - CORE/src/ORM/Table.php, line 1263
App\Controller\NewsController::action_() - APP/Controller/NewsController.php, line 6539
App\Controller\NewsController::get_data() - APP/Controller/NewsController.php, line 5701
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5625
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3436
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317

Notice (8): unserialize() [<a href='https://secure.php.net/function.unserialize'>function.unserialize</a>]: Error at offset 20466 of 20469 bytes [APP/Controller/NewsController.php, line 5571]

Code Context

               {
                      $a=unserialize($line2);
               }

unserialize - [internal], line ??
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5571
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3698
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73

Notice (8): unserialize() [<a href='https://secure.php.net/function.unserialize'>function.unserialize</a>]: Error at offset 4076 of 4085 bytes [APP/Controller/NewsController.php, line 5571]

Code Context

               {
                      $a=unserialize($line2);
               }

unserialize - [internal], line ??
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5571
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::article_show() - APP/Controller/NewsController.php, line 4290
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3822
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161

Code Context

               {
                      $a=unserialize($line2);
               }

unserialize - [internal], line ??
App\Controller\NewsController::action_cache() - APP/Controller/NewsController.php, line 5571
App\Controller\NewsController::cache_action() - APP/Controller/NewsController.php, line 5281
App\Controller\NewsController::article_show() - APP/Controller/NewsController.php, line 4310
App\Controller\NewsController::view() - APP/Controller/NewsController.php, line 3822
Cake\Controller\Controller::invokeAction() - CORE/src/Controller/Controller.php, line 539
Cake\Controller\ControllerFactory::handle() - CORE/src/Controller/ControllerFactory.php, line 140
Cake\Controller\ControllerFactory::invoke() - CORE/src/Controller/ControllerFactory.php, line 115
Cake\Http\BaseApplication::handle() - CORE/src/Http/BaseApplication.php, line 317
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 77
Cake\Http\Middleware\CsrfProtectionMiddleware::process() - CORE/src/Http/Middleware/CsrfProtectionMiddleware.php, line 164
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\I18n\Middleware\LocaleSelectorMiddleware::process() - CORE/src/I18n/Middleware/LocaleSelectorMiddleware.php, line 61
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Http\Middleware\BodyParserMiddleware::process() - CORE/src/Http/Middleware/BodyParserMiddleware.php, line 157
Cake\Http\Runner::handle() - CORE/src/Http/Runner.php, line 73
Cake\Routing\Middleware\RoutingMiddleware::process() - CORE/src/Routing/Middleware/RoutingMiddleware.php, line 161

“删除”衰老基因，可让寿命延长四五十年英媒

趣科技 2015-10-14 07:18:09 转载来源: 网络整理/侵权必删

外媒称，一项前沿性研究发现，如果某些基因被“删除”，人类寿命可以延长多达60%。科学家发现，如果对200多个基因进行“微调”，让它们变得不活跃，那么就可以让人类寿命延长几十年

外媒称，一项前沿性研究发现，如果某些基因被“删除”，人类寿命可以延长多达60%。科学家发现，如果对200多个基因进行“微调”，让它们变得不活跃，那么就可以让人类寿命延长几十年。

据英国《每日快报》网站10月12日报道，这项研究发现，在某些有机体身上，这一做法可以让寿命延长多达60%。这会让英国的人均寿命从81岁增加到一百多岁。

美国巴克老龄化问题研究所和华盛顿大学的专家耗时10年确定了大约238种基因，如果让这些基因“静默”，会让酵母细胞的存活期限延长。

许多相同的基因也存在于包括人类在内的哺乳动物身上，这意味着将它们关闭可能会大幅延长寿命。

研究报告的主要撰写人布赖恩・肯尼迪说：“这项研究让我们对衰老有了更加全面的认识。我们发现的与衰老有关的几乎半数基因都存在于哺乳动物身上。”

他还说：“从理论上讲，这些基因中的任何一个都有可能成为旨在延长寿命的治疗目标。我们现在需要做的是找出哪些基因容易对这样的治疗产生反应。”

巴克研究所的马克・麦考密克说，通过对可以确认的一些衰老基因加以抑制，取得的成果是惊人的。

他还说：“我们取得的最明显的成果是，通过删除一个基因，让酵母细胞的存活期限比正常的此类细胞增加60%左右。”

报道称，为了确定哪些基因与衰老有关系，科学家研究了4698个酵母细胞株。从每个细胞株上删除一个基因，然后观察细胞在停止分裂之前会存活多长时间。

这项研究的结果刊登在美国《细胞-代谢》月刊上。

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